How much protein on Zepbound?

Neither guidance document sets a Zepbound-specific number. The 2025 joint advisory (four US obesity and nutrition societies) reports 1.2–1.6 g per kg per day as proposed during active weight reduction; the 2025 modified-Delphi consensus recommends 1.2–1.5 g per kg of actual body weight per day during the weight-loss phase. Both apply to semaglutide and tirzepatide alike.

The Delphi consensus uses actual body weight. The joint advisory notes that for people with obesity, actual weight can significantly overestimate needs, and offers two alternatives: 1.5 g per kg of fat-free mass if you know your body composition, or an absolute 80–120 g per day.

The joint advisory says prolonged intake at or above 2 g/kg/day should be avoided, and that intake should not fall below 0.4–0.5 g/kg/day. Kidney disease changes the answer — ask your clinician.

Both contain tirzepatide from Eli Lilly. Zepbound is FDA-approved for chronic weight management (weekly injection); the protein guidance above does not differ between them.